The role of inflammation in primary angleclosure glaucoma
Angle closure is a complex heterogeneous disease with multiple contributory factors. It is a disease spectrum that starts with the narrow angles stage, namely, primary angle-closure suspect and culminates in primary angle-closure glaucoma (PACG), characterized by the presence of glaucomatous optic neuropathy. Inflammation has been proposed as one of the potential causal factors for retinal ganglion cell death observed in glaucoma, with research primarily conducted in POAG and its subtypes. Its role in angle-closure pathogenesis is yet to be firmly established; however there are several findings including clinical and histopathological features, imaging-based characteristics and inflammatory mediators that allude to the possible role of inflammation in the pathogenesis of angle-closure disease.
In this chapter, we discuss the evidence supporting the inflammatory basis of angle closure, the mediators, and their implications in disease. Involvement of the inflammatory pathway may provide several avenues to investigate novel therapeutics for treating the angle-closure disease spectrum, and may also facilitate improved patient stratification and management.
Glaucoma Research 2020-2022, pp. 105-112 #10
Edited by: Paul A. Knepper and John R. Samples
© Kugler Publications, Amsterdam, The Netherlands